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1.
Sleep Sci ; 16(Suppl 2): 507-549, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-38370879

RESUMO

Chronic insomnia disorder (simplified in this document as insomnia) is an increasingly common clinical condition in society and a frequent complaint at the offices of different areas of health practice (particularly Medicine and Psychology). This scenario has been accompanied by a significant evolution in treatment, as well as challenges in approaching patients in an appropriately way. This clinical guideline, coordinated by the Brazilian Sleep Association and the Brazilian Association of Sleep Medicine and counting on the active participation of various specialists in the area, encompasses an update on the diagnosis and treatment of insomnia in adults. To this end, it followed a structured methodology. Topics of interest related to diagnosis were written based on theoretical framework, evidence in the literature, and professional experience. As for the topics related to the treatment of insomnia, a series of questions were developed based on the PICO acronym (P - Patient, problem, or population; I - Intervention; C - Comparison, control, or comparator; O - Outcome). The work groups defined the eligible options within each of these parameters. Regarding pharmacological interventions, only the ones currently available in Brazil or possibly becoming available in the upcoming years were considered eligible. Systematic reviews were conducted to help prepare the texts and define the level of evidence for each intervention. The final result is an objective and practical document providing recommendations with the best scientific support available to professionals involved in the management of insomnia.

2.
Sleep ; 45(8)2022 08 11.
Artigo em Inglês | MEDLINE | ID: mdl-35598321

RESUMO

STUDY OBJECTIVES: In field studies using wrist-actimetry, not identifying/handling off-wrist intervals may result in their misclassification as immobility/sleep and biased estimations of rhythmic patterns. By comparing different solutions for detecting off-wrist, our goal was to ascertain how accurately they detect nonwear in different contexts and identify variables that are useful in the process. METHODS: We developed algorithms using heuristic (HA) and machine learning (ML) approaches. Both were tested using data from a protocol followed by 10 subjects, which was devised to mimic contexts of actimeter wear/nonwear in real-life. Self-reported data on usage according to the protocol were considered the gold standard. Additionally, the performance of our algorithms was compared to that of visual inspection (by 2 experienced investigators) and Choi algorithm. Data previously collected in field studies were used for proof-of-concept analyses. RESULTS: All methods showed similarly good performances. Accuracy was marginally higher for one of the raters (visual inspection) than for heuristically developed algorithms (HA, Choi). Short intervals (especially < 2 h) were either not or only poorly identified. Consecutive stretches of zeros in activity were considered important indicators of off-wrist (for both HA and ML). It took hours for raters to complete the task as opposed to the seconds or few minutes taken by the automated methods. CONCLUSIONS: Automated strategies of off-wrist detection are similarly effective to visual inspection, but have the important advantage of being faster, less costly, and independent of raters' attention/experience. In our study, detecting short intervals was a limitation across methods.


Assuntos
Monitorização Ambulatorial , Punho , Algoritmos , Humanos , Autorrelato , Sono
3.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 44(2): 136-146, Apr. 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1374581

RESUMO

Objective: To assess the adherence to a set of evidence-based recommendations to support mental health during the coronavirus disease 2019 (COVID-19) pandemic and its association with depressive and anxiety symptoms. Methods: A team of health workers and researchers prepared the recommendations, formatted into three volumes (1: COVID-19 prevention; 2: Healthy habits; 3: Biological clock and sleep). Participants were randomized to receive only Volume 1 (control), Volumes 1 and 2, Volumes 1 and 3, or all volumes. We used a convenience sample of Portuguese-speaking participants over age 18 years. An online survey consisting of sociodemographic and behavioral questionnaires and mental health instruments (Patient Health Questionnaire-9 [PHQ-9] and Generalized Anxiety Disorder-7 [GAD-7]) was administered. At 14 and 28 days later, participants were invited to complete follow-up surveys, which also included questions regarding adherence to the recommendations. A total of 409 participants completed the study - mostly young adult women holding university degrees. Results: The set of recommendations contained in Volumes 2 and 3 was effective in protecting mental health, as suggested by significant associations of adherence with PHQ-9 and GAD-7 scores (reflecting anxiety and depression symptoms, respectively). Conclusion: The recommendations developed in this study could be useful to prevent negative mental health effects in the context of the pandemic and beyond.

4.
Braz J Psychiatry ; 44(2): 136-146, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35262615

RESUMO

OBJECTIVE: To assess the adherence to a set of evidence-based recommendations to support mental health during the coronavirus disease 2019 (COVID-19) pandemic and its association with depressive and anxiety symptoms. METHODS: A team of health workers and researchers prepared the recommendations, formatted into three volumes (1: COVID-19 prevention; 2: Healthy habits; 3: Biological clock and sleep). Participants were randomized to receive only Volume 1 (control), Volumes 1 and 2, Volumes 1 and 3, or all volumes. We used a convenience sample of Portuguese-speaking participants over age 18 years. An online survey consisting of sociodemographic and behavioral questionnaires and mental health instruments (Patient Health Questionnaire-9 [PHQ-9] and Generalized Anxiety Disorder-7 [GAD-7]) was administered. At 14 and 28 days later, participants were invited to complete follow-up surveys, which also included questions regarding adherence to the recommendations. A total of 409 participants completed the study - mostly young adult women holding university degrees. RESULTS: The set of recommendations contained in Volumes 2 and 3 was effective in protecting mental health, as suggested by significant associations of adherence with PHQ-9 and GAD-7 scores (reflecting anxiety and depression symptoms, respectively). CONCLUSION: The recommendations developed in this study could be useful to prevent negative mental health effects in the context of the pandemic and beyond.


Assuntos
COVID-19 , Pandemias , Adolescente , Ansiedade/prevenção & controle , Ansiedade/psicologia , COVID-19/prevenção & controle , Estudos Transversais , Depressão/epidemiologia , Depressão/prevenção & controle , Depressão/psicologia , Feminino , Humanos , Saúde Mental , Pandemias/prevenção & controle , SARS-CoV-2 , Adulto Jovem
5.
Artigo em Inglês | MEDLINE | ID: mdl-34831655

RESUMO

This study aimed to provide evidence of the validity of the Perceived Physical Ability Scale for Children against an external-objective criterion of the 24 h motor activity pattern assessed through actigraphy. A total of 107 children (60 females; mean age 10.25 ± 0.48) were originally enrolled. Children wore the actigraph model Actiwatch AW64 (Cambridge Neurotechnology Ltd., Fenstanton, UK) for seven days, 24 h per day, around the non-dominant wrist. At the beginning of the actigraphic recording, participants filled in the Perceived Physical Ability Scale for Children. Functional Linear Modeling was used to examine variation in the 24 h motor activity pattern according to the total score in the Perceived Physical Ability Scale for Children. Higher physical self-efficacy was significantly related to greater levels of motor activity in the afternoon. Overall, this pattern of results supports the validity of the Perceived Physical Ability Scale for Children against the external-objective criterion of the 24 h motor pattern. The Perceived Physical Ability Scale for Children could represent a promising endpoint for studies assessing the effectiveness of physical activity promotion interventions.


Assuntos
Actigrafia , Exercício Físico , Criança , Equipamentos Médicos Duráveis , Feminino , Humanos , Modelos Lineares , Punho
6.
J Clin Med ; 10(3)2021 01 20.
Artigo em Inglês | MEDLINE | ID: mdl-33498431

RESUMO

BACKGROUND: Recent studies with the mood rhythm instrument (MRhI) have shown that the presence of recurrent daily peaks in specific mood symptoms are significantly associated with increased risk of psychiatric disorders. Using a large sample collected in Brazil, Spain, and Canada, we aimed to analyze which MRhI items maintained good psychometric properties across cultures. As a secondary aim, we used network analysis to visualize the strength of the association between the MRhI items. METHODS: Adults (n = 1275) between 18-60 years old from Spain (n = 458), Brazil (n = 415), and Canada (n = 401) completed the MRhI and the self-reporting questionnaire (SRQ-20). Psychometric analyses followed three steps: Factor analysis, item response theory, and network analysis. RESULTS: The factor analysis indicated the retention of three factors that grouped the MRhI items into cognitive, somatic, and affective domains. The item response theory analysis suggested the exclusion of items that displayed a significant divergence in difficulty measures between countries. Finally, the network analysis revealed a structure where sleepiness plays a central role in connecting the three domains. These psychometric analyses enabled a psychometric-based refinement of the MRhI, where the 11 items with good properties across cultures were kept in a shorter, revised MRhI version (MRhI-r). LIMITATIONS: Participants were mainly university students and, as we did not conduct a formal clinical assessment, any potential correlations (beyond the validated SRQ) cannot be ascertained. CONCLUSIONS: The MRhI-r is a novel tool to investigate self-perceived rhythmicity of mood-related symptoms and behaviors, with good psychometric properties across multiple cultures.

7.
Sleep Med ; 74: 33-38, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32836184

RESUMO

BACKGROUND/OBJECTIVES: This study aimed to examine the variations of circadian activity rhythm of children according to objective body mass index (BMI) values, using a novel statistical framework (ie, Functional Linear Modeling, FLM), separately for school- and weekend days. METHODS: A total of 107 participants (60 females; mean age: 10.25 ± 0.48 years) wore an actigraph for seven days during a regular school-week. While valid actigraphic data during school days were available for each of these children, this number decreased to 53 (31 females; mean age: 10.28 ± 0.51 years) during weekend days. RESULTS: Examining the school days, significantly higher motor activity in participants with higher BMI was observed from around 4:00 a.m. to 6:00 a.m., with a peak about 5:00 a.m. On the contrary, applying the FLM to the weekend days actigraphic data, no significantly different variation of circadian activity rhythm was observed, according to BMI. CONCLUSIONS: In this specific sample of children, during school days, higher BMI is associated with higher activity level in a specific time window in the second half of nocturnal sleep. The lack of significant findings during weekend days could be explained because of higher variability of get-up time and/or the reduced sample size. Future longitudinal studies could explore if the higher motor activity in that specific time window qualifies as a predictive marker of the development of overweight and obesity. If so, early preventive strategies directed towards those at higher risk could be effectively implemented.


Assuntos
Actigrafia , Ritmo Circadiano , Índice de Massa Corporal , Criança , Feminino , Humanos , Sobrepeso , Sono
8.
Sleep Sci ; 13(1): 37-48, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32670491

RESUMO

OBJECTIVE: To translate the Sleep Hygiene Index (SHI) to Brazilian Portuguese, to describe its psychometric properties and to show its association with sleep quality, daytime sleepiness, risk for sleep apnea and depressive symptoms. METHODS: Thirty subjects participated in the cultural adaptation and the item clarity evaluation. Twenty subjects answered the instrument in three different time-points for test-retest reliability. Eighty adult workers completed the SHI, the Pittsburgh Sleep Quality Index (PSQI), the Epworth Sleepiness Scale (ESS), the Beck Depression Inventory (BDI) and the STOP-BANG (S-B). RESULTS: SHI shows an acceptable internal consistency (Cronbach's α=0.75), as well as a high reproducibility (intraclass correlation=0.972, p<0.01). The three final factors of confirmatory factor analysis extract an average of 48.22% of the total sample variance. Worse sleep hygiene (higher SHI score) correlated with poor sleep quality (r=0.398, p<0.001), excessive daytime sleepiness (r=0.406, p<0.001) and depressive symptoms (r=0.324, p=0.003). No correlations with S-B were found. CONCLUSIONS: SHI presents satisfactory-to-optimal psychometric properties. This instrument is useful for treatment planning and management of sleep hygiene practices. Thus, it represents a reliable way of assessing sleep hygiene quantitatively in both research and clinical settings.

9.
BMC Psychol ; 8(1): 35, 2020 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-32303262

RESUMO

BACKGROUND: Disruption of biological rhythms has been linked to the pathophysiology of mental disorders. However, little is known regarding the rhythmicity of mood symptoms due to the lack of validated clinical questionnaires. A better understanding of the rhythmicity of mood symptoms can help identifying individuals whose severity of mood symptoms follows an altered circadian rhythm. The objective of this study was to validate the English version of the Mood Rhythm Instrument (MRhI), a self-reported measure of self-perceived rhythmicity of mood symptoms and behaviours, in a sample of the general population from Canada. METHODS: After the translation process, the final English version of the Mood Rhythm Instrument (MRhI-English) was applied on participants recruited at McMaster University and St. Joseph's Healthcare Hamilton campuses. Individuals were also asked to answer the Reduced Morningness-Eveningness Questionnaire (rMEQ). RESULTS: Four hundred one individuals completed the English version of the MRhI and the rMEQ. The MRhI-English presented a Cronbach's alpha of 0.75. The factorial analysis grouped the MRhI-15 items in 3 factors (cognitive, affective and somatic), with affective items having a lower frequency of self-reported 24-h peaks. Comparison between sexes showed that women reported a higher frequency of daily peaks in irritability, anxiety, sadness and talking to friends, while men exhibited peaks more frequently in problem-solving, sexual arousal and motivation to exercise. CONCLUSIONS: Our findings suggest that the English version of the MRhI displayed good internal consistency. Future directions will include the use of the MRhI instrument in individuals with mood disorders, aiming to provide a better understanding of the relationship between daily patterns of mood variability and mental health outcomes.


Assuntos
Afeto , Ritmo Circadiano , Transtornos do Humor/diagnóstico , Testes Psicológicos , Inquéritos e Questionários , Adolescente , Adulto , Afeto/fisiologia , Ansiedade/diagnóstico , Canadá , Ritmo Circadiano/fisiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Autorrelato , Tradução , Adulto Jovem
10.
Sleep Health ; 6(2): 172-178, 2020 04.
Artigo em Inglês | MEDLINE | ID: mdl-32111524

RESUMO

OBJECTIVES: The objective was to describe (1) the type, (2) the amount of use, and (3) the time of usage of electronic devices, for school days and weekends, as well as its impact on adolescents' sleep quality. DESIGN: A cross-sectional study using hierarchical regressions accounting for confounding sleep-related variables was used. SETTING: The participants were from six public schools in Porto Alegre, Brazil. PARTICIPANTS: The participants included 177 students of both sexes aged between 11 and 18 years. MEASUREMENTS: An electronic usage diary assessed the span of time during which the electronic device was used (separated by "TV and computer monitors", "tablets, e-readers and portable video games," and "cell phones") for school days and weekends. The Munich Chronotype Questionnaire was used to assess sleep duration, midpoint of sleep, and social jetlag. Sleep quality was assessed using the Pittsburgh Sleep Quality Index. RESULTS: Greater nighttime use and last time of use of cell phones at night are associated with worse sleep quality in univariate analyses. A hierarchical regression model shows that poor sleep quality associates with shorter sleep duration on school days and with a delayed midpoint of sleep on weekends. Electronic device use did not reach statistical significance in the regression model with confounding factors. CONCLUSIONS: Adequate sleep duration is imperative to maintain a good sleep quality on school days, independently of the use of cell phones. It is important to underpin the need for evaluation of sleep phase and chronotype in future research on the topic aiming to elucidate its relationship with electronic use on school-free days.


Assuntos
Eletrônica/estatística & dados numéricos , Sono , Estudantes/psicologia , Adolescente , Brasil , Telefone Celular/estatística & dados numéricos , Criança , Computadores/estatística & dados numéricos , Estudos Transversais , Feminino , Humanos , Masculino , Instituições Acadêmicas , Estudantes/estatística & dados numéricos , Inquéritos e Questionários , Televisão/estatística & dados numéricos , Fatores de Tempo , Jogos de Vídeo/estatística & dados numéricos
11.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 42(1): 54-62, Jan.-Feb. 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1055351

RESUMO

Objective: Although studies have shown an association between poor sleep and chronotype with psychiatric problems in young adults, few have focused on identifying multiple concomitant risk factors. Methods: We assessed depressive symptoms (Beck Depression Inventory [BDI]), circadian typology (Morningness-Eveningness Questionnaire [MEQ]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), perceived stress (Perceived Stress Scale [PSS]), social rhythm (Social Rhythm Metrics [SRM]), and salivary cortisol (morning, evening and night, n=37) in 236 men (all 18 years old). Separate analyses were conducted to understand how each PSQI domain was associated with depressive symptoms. Results: Depressive symptoms were more prevalent in individuals with higher perceived stress (prevalence ratio [PR] = 6.429, p < 0.001), evening types (PR = 2.58, p < 0.001) and poor sleepers (PR = 1.808, p = 0.046). Multivariate modeling showed that these three variables were independently associated with depressive symptoms (all p < 0.05). The PSQI items subjective sleep quality and sleep disturbances were significantly more prevalent in individuals with depressive symptoms (PR = 2.210, p = 0.009 and PR = 2.198, p = 0.008). Lower levels of morning cortisol were significantly associated with higher depressive scores (r = -0.335; p = 0.043). Conclusion: It is important to evaluate multiple factors related to sleep and chronotype in youth depression studies, since this can provide important tools for comprehending and managing mental health problems.


Assuntos
Humanos , Masculino , Adolescente , Transtornos do Sono-Vigília/psicologia , Estresse Psicológico/psicologia , Hidrocortisona/análise , Transtornos Cronobiológicos/psicologia , Depressão/etiologia , Militares/psicologia , Escalas de Graduação Psiquiátrica , Valores de Referência , Saliva/metabolismo , Sono/fisiologia , Fatores de Tempo , Análise Multivariada , Fatores de Risco , Análise de Variância , Estatísticas não Paramétricas , Depressão/metabolismo , Autorrelato
12.
Braz J Psychiatry ; 42(1): 54-62, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31166545

RESUMO

OBJECTIVE: Although studies have shown an association between poor sleep and chronotype with psychiatric problems in young adults, few have focused on identifying multiple concomitant risk factors. METHODS: We assessed depressive symptoms (Beck Depression Inventory [BDI]), circadian typology (Morningness-Eveningness Questionnaire [MEQ]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), perceived stress (Perceived Stress Scale [PSS]), social rhythm (Social Rhythm Metrics [SRM]), and salivary cortisol (morning, evening and night, n=37) in 236 men (all 18 years old). Separate analyses were conducted to understand how each PSQI domain was associated with depressive symptoms. RESULTS: Depressive symptoms were more prevalent in individuals with higher perceived stress (prevalence ratio [PR] = 6.429, p < 0.001), evening types (PR = 2.58, p < 0.001) and poor sleepers (PR = 1.808, p = 0.046). Multivariate modeling showed that these three variables were independently associated with depressive symptoms (all p < 0.05). The PSQI items subjective sleep quality and sleep disturbances were significantly more prevalent in individuals with depressive symptoms (PR = 2.210, p = 0.009 and PR = 2.198, p = 0.008). Lower levels of morning cortisol were significantly associated with higher depressive scores (r = -0.335; p = 0.043). CONCLUSION: It is important to evaluate multiple factors related to sleep and chronotype in youth depression studies, since this can provide important tools for comprehending and managing mental health problems.


Assuntos
Transtornos Cronobiológicos/psicologia , Depressão/etiologia , Hidrocortisona/análise , Militares/psicologia , Transtornos do Sono-Vigília/psicologia , Estresse Psicológico/psicologia , Adolescente , Análise de Variância , Depressão/metabolismo , Humanos , Masculino , Análise Multivariada , Escalas de Graduação Psiquiátrica , Valores de Referência , Fatores de Risco , Saliva/metabolismo , Autorrelato , Sono/fisiologia , Estatísticas não Paramétricas , Fatores de Tempo
13.
J Clin Psychol ; 75(6): 970-984, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-30689206

RESUMO

OBJECTIVES: This study was aimed to evaluate the effects of the Breathworks' Mindfulness for Stress 8-week course on depressive and psychiatric symptoms, and on positive and negative affects, compared with active control and wait list. METHOD: A total of 84 primary care health professionals enrolled in the study, in quasi-experimental research design. The scales Beck Depression Inventory, Self-Reporting Questionnaire, Positive and Negative Affect Schedule, Self-Compassion Scale, and Five Facets of Mindfulness Questionnaire were applied before and after the interventions. RESULTS: Depressive symptoms, psychiatric symptoms, and negative affects had a statistically significant decrease before postintervention evaluations in Mindfulness for Stress group, and the levels of self-compassion and observe and non-reactivity dimensions of mindfulness improved after the intervention. CONCLUSIONS: The Mindfulness for Stress program can be considered a feasible group intervention to improve the mental health of healthcare professionals.


Assuntos
Sintomas Afetivos/terapia , Depressão/terapia , Empatia , Pessoal de Saúde/psicologia , Transtornos Mentais/terapia , Atenção Plena , Autoimagem , Estresse Psicológico/terapia , Adulto , Brasil , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Atenção Plena/métodos
14.
Ther Adv Psychopharmacol ; 9: 2045125319881927, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31908762

RESUMO

BACKGROUND: To date, no biomarker has been able to predict antidepressant response at an early blockade of norepinephrine or serotonin uptake. The transient nocturnal increase in plasma melatonin levels is upregulated by blocking these uptakes. The aim of this study was to test whether fluoxetine increase in urinary 6-sulfatoxymelatonin (aMT6s) is an indicator of serotonin uptake blockade. METHODS: A total of 20 women (35-45 years of age) recruited from the community had a diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-IV. Depressive symptoms were evaluated by the Beck Depression Inventory (BDI). Participants were instructed to take 20 mg of fluoxetine every morning. Every 4 weeks, the dose could be increased by 20 mg until symptom remission. The concentration of aMT6s was evaluated in overnight urine samples collected 1 day before and 1 day after the first fluoxetine dose. RESULTS: An increase in aMT6s correlated to a decrease in BDI score evaluated on day 45 (ρ = -0.67, p = 0.024) was observed. CONCLUSIONS: Nocturnal increase in urinary aMT6s after the first day of medication use links the early mechanism of action of fluoxetine to its clinical output 45 days later. Thus, the relationship between urinary aMT6s excretion 1 day before/1 day after is a biomarker for predicting clinical output earlier, reducing illness burden and health care costs.

15.
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 40(4): 376-381, Oct.-Dec. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-959259

RESUMO

Objective: Sleep apnea has been associated with anxiety, but the mechanisms of the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative stress, which might enhance anxiety-like behavior in rodents. To clarify the apnea-anxiety connection, we tested the effect of intermittent hypoxia, a model of sleep apnea, on the anxiety behavior of mice. Methods: The rodents were exposed daily to 480 one-minute cycles of intermittent hypoxia to a nadir of 7±1% inspiratory oxygen fraction or to a sham procedure with room air. After 7 days, the mice from both groups were placed in an elevated plus maze and were video recorded for 10 min to allow analysis of latency, frequency, and duration in open and closed arms. Glyoxalase-1 (Glo1) and glutathione reductase-1 (GR1) were measured in the cerebral cortex, hippocampus, and striatum by Western blotting. Results: Compared to controls, the intermittent hypoxia group displayed less anxiety-like behavior, perceived by a statistically significant increase in the number of entries and total time spent in open arms. A higher expression of GR1 in the cortex was also observed. Conclusion: The lack of a clear anxiety response as an outcome of intermittent hypoxia exposure suggests the existence of additional layers in the anxiety mechanism in sleep apnea, possibly represented by sleepiness and irreversible neuronal damage.


Assuntos
Animais , Masculino , Ansiedade/etiologia , Síndromes da Apneia do Sono/complicações , Glutationa Redutase/análise , Lactoilglutationa Liase/análise , Hipóxia/complicações , Ansiedade/diagnóstico , Ansiedade/fisiopatologia , Síndromes da Apneia do Sono/enzimologia , Síndromes da Apneia do Sono/fisiopatologia , Síndromes da Apneia do Sono/psicologia , Córtex Cerebral/enzimologia , Estresse Oxidativo/fisiologia , Corpo Estriado/enzimologia , Modelos Animais de Doenças , Glutationa Redutase/metabolismo , Lactoilglutationa Liase/metabolismo , Hipóxia/enzimologia , Hipóxia/psicologia , Camundongos Endogâmicos BALB C
16.
Front Psychiatry ; 9: 370, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30186188

RESUMO

Background: The Mood Rhythm Instrument (MRI) is a new self-report questionnaire that aims to assess, the presence, and timing of daily patterns of mood-related symptoms. Here, we examined the reliability of the MRI against a prospective daily investigation over the course of 15 days. As a secondary aim, we examined whether the number of items with a perceived daily pattern correlated with severity of depressive symptoms and psychological well-being. Methods: Thirty-two participants recruited from the general population were asked to prospectively fill out a daily version of the MRI (MRI-d) for 15 days. On the 16th day, they filled out the MRI, the Beck Depression Inventory (BDI) and the World Health Organization 5-item well-being index (WHO-5). Results: The MRI showed high agreement with the MRI-d, which suggests that the MRI is a valid tool to assess daily patterns of mood symptoms. The number of mood symptoms perceived as having daily peaks correlated positively with BDI scores and negatively with WHO-5 scores. Conclusions: The MRI might be a valid tool to investigate the presence of daily patterns and the timing of mood-related factors.The MRI does not seem to be influenced by recall or recency biases. Future studies should test the usefulness of this new clinical instrument in individuals with mood disorders, as well as its ability to detect changes in the daily timing of mood symptoms before and after treatment.

17.
Braz J Psychiatry ; 40(4): 376-381, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30110090

RESUMO

OBJECTIVE: Sleep apnea has been associated with anxiety, but the mechanisms of the sleep apnea-anxiety relationship are unresolved. Sleep apnea causes oxidative stress, which might enhance anxiety-like behavior in rodents. To clarify the apnea-anxiety connection, we tested the effect of intermittent hypoxia, a model of sleep apnea, on the anxiety behavior of mice. METHODS: The rodents were exposed daily to 480 one-minute cycles of intermittent hypoxia to a nadir of 7±1% inspiratory oxygen fraction or to a sham procedure with room air. After 7 days, the mice from both groups were placed in an elevated plus maze and were video recorded for 10 min to allow analysis of latency, frequency, and duration in open and closed arms. Glyoxalase-1 (Glo1) and glutathione reductase-1 (GR1) were measured in the cerebral cortex, hippocampus, and striatum by Western blotting. RESULTS: Compared to controls, the intermittent hypoxia group displayed less anxiety-like behavior, perceived by a statistically significant increase in the number of entries and total time spent in open arms. A higher expression of GR1 in the cortex was also observed. CONCLUSION: The lack of a clear anxiety response as an outcome of intermittent hypoxia exposure suggests the existence of additional layers in the anxiety mechanism in sleep apnea, possibly represented by sleepiness and irreversible neuronal damage.


Assuntos
Ansiedade/etiologia , Glutationa Redutase/análise , Hipóxia/complicações , Lactoilglutationa Liase/análise , Síndromes da Apneia do Sono/complicações , Animais , Ansiedade/diagnóstico , Ansiedade/fisiopatologia , Córtex Cerebral/enzimologia , Corpo Estriado/enzimologia , Modelos Animais de Doenças , Glutationa Redutase/metabolismo , Hipóxia/enzimologia , Hipóxia/psicologia , Lactoilglutationa Liase/metabolismo , Masculino , Camundongos Endogâmicos BALB C , Estresse Oxidativo/fisiologia , Síndromes da Apneia do Sono/enzimologia , Síndromes da Apneia do Sono/fisiopatologia , Síndromes da Apneia do Sono/psicologia
18.
Sci Rep ; 8(1): 11402, 2018 07 30.
Artigo em Inglês | MEDLINE | ID: mdl-30061722

RESUMO

Despite emerging evidence that disruption in circadian rhythms may contribute to the pathophysiology of psychiatric disorders, there is a significant knowledge gap on the rhythmicity of psychological symptoms. Here, we aimed at investigating the rhythmicity of mood symptoms in individuals at risk for psychiatric disorders. 391 Brazilian and 317 Spanish participants completed the Self-Reporting Questionnaire-20 for non-psychotic mental disorders; the Mood Rhythm Instrument was used to assess rhythmicity of mood symptoms and the Munich ChronoType Questionnaire to assess sleep patterns. We found that the rhythmicity of specific mood-related symptoms and behaviors, particularly pessimism and motivation to exercise, were associated with being at risk for psychiatric disorders, even after controlling for sleep timing, sleep deficit, and season of data collection. We also found that the peak of some mood symptoms and behaviors were different between individuals at high vs. low risk for psychiatric disorders, with specific differences between countries. These results are consistent with previous research showing that circadian misalignment is associated with higher risk for mental health conditions. These findings also suggest that lifestyle changes preventing circadian misalignment might be useful to reduce the risk of psychiatric disorders, where cultural differences must be taken into account.


Assuntos
Afeto/fisiologia , Ritmo Circadiano/fisiologia , Transtornos Mentais/fisiopatologia , Brasil , Feminino , Humanos , Modelos Logísticos , Imageamento por Ressonância Magnética , Masculino , Fatores de Risco , Autorrelato , Espanha , Inquéritos e Questionários , Adulto Jovem
19.
J. pediatr. (Rio J.) ; 93(1): 64-69, Jan.-Feb. 2017. tab
Artigo em Inglês | LILACS | ID: biblio-841327

RESUMO

Abstract: Objective: The present study aimed to investigate the relationship between physical self-efficacy and body mass index in a large sample of schoolchildren. Methods: The Perceived Physical Ability Scale for Children was administered to 1560 children (50.4% boys; 8-12 years) from three different countries. Weight and height were also recorded to obtain the body mass index. Results: In agreement with the literature, the boys reported greater perceived physical self-efficacy than girls. Moreover, the number of boys who are obese is double that of girls, while the number of boys who are underweight is half that found in girls. In the linear regression model, the increase in body mass index was negatively related to the physical self-efficacy score, differently for boys and girls. Furthermore, age and nationality also were predictors of low physical self-efficacy only for girls. Conclusion: The results of this study reinforce the importance of psychological aspect of obesity, as the perceived physical self-efficacy and body mass index were negatively associated in a sample of schoolchildren for boys and girls.


Resumo: Objetivo: Investigar a relação entre a autoeficácia física e o índice de massa corporal em uma grande amostra de crianças em idade escolar. Métodos: A Escala de Capacidade Física Percebida para Crianças foi administrada a 1.560 crianças (50,4% meninos; 8-12 anos) de três países diferentes. O peso e a altura também foram registrados para obter o índice de massa corporal. Resultados: De acordo com a literatura, os meninos relataram maior autoeficácia física percebida do que as meninas. Além disso, o número de meninos obesos é o dobro do de meninas, ao passo que o número de meninos abaixo do peso é metade do de meninas. No modelo de regressão linear, o aumento no índice de massa corporal foi negativamente relacionado ao escore de autoeficácia física, diferentemente em meninos e meninas. Além disso, a idade e a nacionalidade também foram preditoras de autoeficácia física baixa apenas para meninas. Conclusão: Os resultados deste estudo reforçam a importância do aspecto psicológico da obesidade, uma vez que a autoeficácia física percebida e o índice de massa corporal foram negativamente associados em uma amostra de crianças em idade escolar para meninos e meninas.


Assuntos
Humanos , Masculino , Feminino , Criança , Índice de Massa Corporal , Autoeficácia , Sobrepeso/epidemiologia , Obesidade/epidemiologia , Espanha/epidemiologia , Brasil/epidemiologia , Fatores Sexuais , Estudos Transversais , Fatores Etários , Sobrepeso/psicologia , Itália/epidemiologia , Obesidade/psicologia
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